HIGHLIGHTS
SUMMARY
Accordingly, emerging evidence in mouse models recapitulating human familial AD (e_g, 3xTg-AD, 5XFAD) suggest that cerebrovascular remodeling and/or degeneration occurs before the onset of classical AD hallmarks, such as the presence of Aβ plaques and neurofibrillary tangles. Employing the novel vessel painting approach to study cortical regions in AD model mice, the authors tested the hypothesis that cerebrovascular structural profiles are modified by the onset of AD pathology in both males and females. The authors temporally examined aging 3xTg-AD mice as they progressed from young (1-3 months), cognitively impaired (4 . . .
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