HIGHLIGHTS
- who: Alexei A. Sharov from the Laboratory of Genetics, u20116825, USA Laboratory, Keio University have published the research work: Atlas of regulated target genes of transcription factors (ART-TF) in human ES cells, in the Journal: (JOURNAL)
- what: For simplicity the authors focus on the dominant direction of gene_expression change: upregulation of target genes - for activator TFs, and downregulation - for repressor TFs. Naturally, the study has some limitations which are necessary to mention here. Third, the approach is focused only on the canonical effect of TFs on target genes via binding to promoters and enhancers . . .
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