Inhibition of atr reverses a mitochondrial respiratory insufficiency

HIGHLIGHTS

• who: Megan B. Borror and collaborators from the The Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San San Antonio, TX, USA have published the Article: Inhibition of ATR Reverses a Mitochondrial Respiratory Insufficiency, in the Journal: Cells 2022, 1731 of /2022/
• what: The authors show that removal of ATL-1 but not ATM-1 worm orthologs of ATR and ATM respectively key nuclear DNA damage checkpoint proteins in human cells unexpectedly lessens the severity of ETC dysfunction. The authors examined the role of other checkpoint proteins in modulating . . .
  

   

  

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