HIGHLIGHTS
- who: Do Hoon Kwon from the Duke University have published the research work: Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
- what: Not only do the authors report the fully open state of full-length TRPV1 via the single modality stimulation of RTx binding, but the analysis also provides insights into the conformational trajectory of RTxdependent TRPV1 opening, including critical intermediate states, providing a basis for the long range allostery between RTx binding and pore opening. The authors reason that the two intermediate states at 4 u00b0C . . .
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