Traditional chinese decoction si zhi wan attenuates ovariectomy (ovx)-induced bone loss by inhibiting osteoclastogenesis and promoting apoptosis of mature osteoclasts

HIGHLIGHTS

• who: Si Zhi Wan and colleagues from the Zunyi Medical University, China have published the research work: Traditional Chinese decoction Si Zhi Wan attenuates ovariectomy (OVX)-induced bone loss by inhibiting osteoclastogenesis and promoting apoptosis of mature osteoclasts, in the Journal: (JOURNAL)
• what: The authors explored this phenomenon in_vitro and in_vivo. The authors demonstrate that SZW inhibits the NF-u03baB signaling pathway by modulating the phosphorylation of Iu03baB and P65 in BMMs, consistent with in_vivo results. In this study, the anti-osteoclastogenesis effect of SZW in_vitro was evaluated using RAW264.7 cells.
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