Unusual tetrahydropyridoindole-containing tetrapeptides with human nicotinic acetylcholine receptors targeting activity discovered from antarctica-derived psychrophilic pseudogymnoascus sp. hdn17-933

HIGHLIGHTS

  • who: Xuewen Hou et al. from the Ocean University of China, Qingdao, China have published the research work: Unusual Tetrahydropyridoindole-Containing Tetrapeptides with Human Nicotinic Acetylcholine Receptors Targeting Activity Discovered from Antarctica-Derived Psychrophilic Pseudogymnoascus sp. HDN17-933, in the Journal: (JOURNAL) of 28/09/2016
  • what: To explain the different inhibitory activities and obtain further insight into the mechanism of nAChRs inhibition, molecular docking studies were carried out to explore the possible binding modes of compounds 1-6 and key interactions with nAChRs.

SUMMARY

    The signals of α-proton, the characteristic . . .

     

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