Cryptic in vitro ubiquitin ligase activity of hdmx towards p53 is probably regulated by an induced fit mechanism

HIGHLIGHTS

• who: Bioscience Reports ( and collaborators from the Institut Universidad Autou0301noma de have published the article: Cryptic in vitro ubiquitin ligase activity of HDMX towards p53 is probably regulated by an induced fit mechanism, in the Journal: (JOURNAL) of 04/07/2022
• what: The authors show that phospho-mutation does not change the conformation of the protein but HDMX is indeed an E3 ubiquitin ligase in vitro; however in vivo no activity was found. In Figure 4C, the authors show the p53 profile of ubiquitination HDM2-dependent.
• how: For HDMX the authors employed anti . . .
  

   

  

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