Pain

HIGHLIGHTS

• who: The neuronal tyrosine kinase and collaborators from the DepartmentUniversity of Calgary, Calgary, Alberta, Canada have published the Article: pain, in the Journal: (JOURNAL)
• what: The authors show that inflammation or injury enhanced expression in a subset of TRPV1+ sensory neurons. The authors propose that clinically approved ALK inhibitors used for non-small cell lung cancer and neuroblastomas could be repurposed to treat persistent pain conditions. The authors report that ALKAL2, the physiological ligand of ALK, is enriched in TRPV1 nociceptors.
• how: The authors examined its pronociceptive properties and tested the analgesic efficacy . . .
  

   

  

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