HIGHLIGHTS
- who: Liyuan Zhou from the LaboratoryZhejiang University China have published the research work: Long-read sequencing unveils high-resolution HPV integration and its oncogenic progression in cervical cancer, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
- what: The authors demonstrate the induction of HPV-mediated translocations between chromosomes and the formation of extrachromosomal circular (ECC) human-virus hybrid DNA structures in these clonal integration events. It is generally believed that HPV integration is via the introduction of a viral genome sequence into the host genome while this study shows another potential form of integration where HPV . . .
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