Dimerization tendency of 3clpros of human coronaviruses based on the x-ray crystal structure of the catalytic domain of sars-cov-2 3clpro

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  • who: Seri Jo and collaborators from the College of Pharmacy and Graduates School of Pharmaceutical Sciences, Ewha Womans University have published the research work: Dimerization Tendency of 3CLpros of Human Coronaviruses Based on the X-ray Crystal Structure of the Catalytic Domain of SARS-CoV-2 3CLpro, in the Journal: (JOURNAL)
  • what: The authors determined the X-ray_crystal_structure of the catalytic domain of SARS-CoV-2 3CLpro and performed fluorescence resonance energy transfer (FRET)based enzymatic assays against entire and catalytic domains. The relatively weak interaction exerted by the DM-loops between domain IIIs seems . . .

     

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