Surface hydration protects cystic fibrosis airways from infection by restoring junctional networks

HIGHLIGHTS

  • who: Juliette L. Simonin and collaborators from the Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland have published the research: Surface Hydration Protects Cystic Fibrosis Airways from Infection by Restoring Junctional Networks, in the Journal: Cells 2022, 1587 of /2022/
  • what: The authors show here that P. aeruginosa-induced cytotoxicity of CFTR-deficient airway epithelial_cells is reduced by the presence of a liquid on an apical surface, irrespective of its composition or expression of a functional CFTR at the apical membrane. This protection was associated with an increased TEER . . .

     

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