HIGHLIGHTS
- who: Xin Li from the (UNIVERSITY) have published the research work: Lipid metabolism dysfunction induced by age-dependent DNA methylation accelerates aging, in the Journal: (JOURNAL) of 24/02/2022
- what: The authors show that lack of Elovl2 leads to a decline in PUFA synthesis and the accumulation of short fatty_acids including PUFA precursors in ER, altering mitochondrial energy metabolism and resulting in chronic ER stress and mitochondria dysfunction.
- how: These results indicated that Elovl2 loci showed a conserved pattern of increased DNA methylation and reduced expression in both the human fibroblast cell . . .
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