Salubrinal induces fetal hemoglobin expression via the stress-signaling pathway in human sickle erythroid progenitors and sickle cell disease mice

HIGHLIGHTS

• who: Nicole H. Lopez and colleagues from the Department of Biochemistry and Cancer Biology, Augusta University, Augusta, GA, United States of have published the Article: Salubrinal induces fetal hemoglobin expression via the stress-signaling pathway in human sickle erythroid progenitors and sickle cell disease mice, in the Journal: PLOS ONE of 31/05/2022
• what: The aim of the study was to determine whether salubrinal (SAL) a selective protein phosphatase 1 inhibitor induces HbF expression through the stress-signaling pathway by activation of peIF2u03b1 and ATF4 trans-activation in the u03b3-globin gene promoter. Since . . .
  

   

  

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