Large scale phenotype imputation and in vivo functional validation implicate adamts14 as an adiposity gene

HIGHLIGHTS

• who: Katherine A. Kentistou from the Mouse husbandry The Adamts14-/- mice were created as described in, and obtained in collaboration with the Colige group at the University of LiegeBriefly, a genetrap cassette was inserted between exons , and , in ES cells. Clones were fused to, bl/, blastocysts to obtain mosaics that were crossed to give homozygous mice. The protein was not detectable in embryonic or adult skin in homozygous mice. Sperm from heterozygous (Adamts14+/-) C BL/ J animals was shipped to Edinburgh frozen and used to perform in vitro fertilisation (IVF) to C BL/ J females, at the . . .
  

   

  

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