Synthesis and preclinical evaluation of novel

HIGHLIGHTS

  • who: Jan-Philip Kunert from the University Munich (TUM), Waltheru2011Meiu00dfneru2011Str, Garching, Germany have published the article: Synthesis and preclinical evaluation of novel, in the Journal: (JOURNAL)
  • what: As the authors aimed for differential (and primarily reduced) lipophilicity and plasma_protein binding of the novel ligands, d-glutamate (d-Glu; negatively charged), d-phenylalanine (d-Phe; aromatic, uncharged), and 4-amino-d-phenylalanine (d-(4-NH2) Phe; aromatic, positively charged) were used as variable amino_acids to introduce different charges and optional aromatic moieties. The authors report the comparative preclinical evaluation of three 99mTc-labeled N4-PSMA ligands . . .

     

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