HIGHLIGHTS
SUMMARY
The Connectivity Map (CMap) project is the first powerful drug repurposing platform that embedded gene_expression responses of 4 human cell lines treated with different doses of a large collection of FDAapproved compounds. Taking a step forward, the NIHsupported Library of Integrated Network-Based Cellular Signatures (LINCS) enriched the transcriptomic databases of the CMap project by integrating the gene_expression profiles of more than 60 cell lines before and after exposure to more than 20,000 perturbagens. The authors also deployed a personalized drug repurposing pipeline to identify FDAapproved drugs or patented compounds for different indications . . .
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