Mechanoreceptor piezo1 is downregulated in multiple sclerosis brain and is involved in the maturation and migration of oligodendrocytes in vitro

HIGHLIGHTS

  • who: Aleksandra Rutkowska from the University, China have published the article: Mechanoreceptor Piezo1 Is Downregulated in Multiple Sclerosis Brain and Is Involved in the Maturation and Migration of Oligodendrocytes in vitro, in the Journal: (JOURNAL)
  • what: The authors aimed to examine the presence of Piezo1 in the oligodendrocyte lineage cells in the human brain.
  • how: The data showed that activation of Piezo1 with its agonist Yoda-1 led to the induction of Ca2+ waves in the MO3.13 oligodendrocytes . The data showed that MBP mRNA levels significantly increase with maturation at 72 h . . .

     

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