HIGHLIGHTS
SUMMARY
In 2012, Dixon et_al proposed a new type of irondependent programmed cell death induced by erastin and RSL3 and other small_molecules, called ferroptosis, which is mainly characterized by the generation of reactive oxygen species (ROS), lipid peroxidation and iron accumulation. When a specific small_molecule compound interacts with a specific target in the cell, it will cause the reduction in antioxidants such as glutathione (GSH) and glutathione peroxidase 4 (GPX4), and the antioxidant capacity of the cell will be weakened. To tumor cells, the tumor microenvironment (TME) is also rich in a large number of . . .
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