HIGHLIGHTS
- who: . and colleagues from the University of Bremen, Germany have published the article: Balanced activities of Hsp70 and the ubiquitin proteasome system underlie cellular protein homeostasis, in the Journal: (JOURNAL)
- what: The authors show that reducing UPS activity rescues growth and proteostasis defects of the Hsp70 capacity mutants. The authors focused the further analysis on cells harboring a rpn4 deletion to avoid additional effects of unassembled proteasomes accumulating upon irc25 deletion. In the current analysis the authors focused on the nuclear sequestrase Btn2 as its deletion conferred the strongest growth defects in Hsp70 capacity mutants . . .
If you want to have access to all the content you need to log in!
Thanks :)
If you don't have an account, you can create one here.