HIGHLIGHTS
SUMMARY
SCN has been acknowledged to act as master pacemaker, upon which the circadian rhythmicity of many peripheral organs depends, including pituitary and pineal gland, liver and adipose_tissue, which, when disconnected from hierarchical SCN control, maintain a proper chronobiological autonomy. Taking into account the pre-eminent role exerted by PPARs in the regulation of glucose and lipid metabolism in the liver, muscles and adipose_tissue, as well as in the proliferation/differentiation of adipocyte progenitors, the strong interrelationships among chronobiology, obesity and metabolic syndrome are not surprising. In this context, clock mutant mice, as other genetically . . .
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