Dual roles of interleukin-33 in cognitive function by regulating central nervous system inflammation

HIGHLIGHTS

• who: Xiuqin Rao from the (UNIVERSITY) have published the Article: Dual roles of interleukin-33 in cognitive function by regulating central nervous system inflammation, in the Journal: (JOURNAL)

SUMMARY

Interleukin-33 (IL-33) is a recently discovered multifunctional member of the IL-1 family, that is constitutively expressed in the CNS tissues of both humans and mice, mainly in endothelial cells, astrocytes, and oligodendrocytes (Fig 1). Suppression of tumorigenicity 2 (ST2), the specific receptor of IL-33, is mainly expressed in microglia and astrocytes, but also in mast cells, T helper 2 cells . . .

 



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