Transcriptional and genetic alterations of cuproptosis-related genes correlated to malignancy and immune-infiltrate of esophageal carcinoma

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SUMMARY

    The higher CRGs score Official journal of CDDpress 2 suggested a bad survival ending while a more immune infiltration in ESCA, which could be explained by the increased stability of PDL1 and the increased proportion of bystander T_cells. The analysis revealed the significance of cuproptosis in ESCA and may have therapeutic potential in activating the bystander T_cells in ESCA. Unexpectedly, as shown in Fig 8A, the heat map of immune cells exhibited a much more infiltration in the high CRGs-score group, such as activated CD4 + T_cells, activated CD8 + T_cells, memory T_cells, and NK . . .

     

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