Loss of rhoe function in dermatofibroma promotes disorganized dermal fibroblast extracellular matrix and increased integrin activation

HIGHLIGHTS

• who: Sofia Endzhievskaya from the Randall Centre for Cell and Molecular Biophysics, King`s College London, London, UK Department of Dermatology, National Cheng Kung University Hospital, College of Medicine have published the research: Loss of RhoE function in dermatofibroma promotes disorganized dermal fibroblast extracellular matrix and increased integrin activation, in the Journal: (JOURNAL) of 16/05/2022
• what: The authors demonstrate that the 692C>T (p.T231M) variant in RND3 results in enhanced dermal fibroblast proliferation and increased synthesis of disorganized native ECM. This study investigated the contribution of RhoE to dermal fibroblast ECM synthesis . . .
  

   

  

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