Enhancer clusters drive type i interferon-induced trail overexpression in cancer, and its intracellular protein accumulation fails to induce apoptosis

HIGHLIGHTS

  • who: Carolina Di Benedetto and collaborators from the Department of Radiation Oncology, University of California, San Francisco (UCSF), San Francisco, CA, USA have published the Article: Enhancer Clusters Drive Type I Interferon-Induced TRAIL Overexpression in Cancer, and Its Intracellular Protein Accumulation Fails to Induce Apoptosis, in the Journal: Cancers 2023, x of 15/01/2022
  • what: The authors show here that in certain cancer cells is upregulated by enhancer clusters potent genomic regulatory regions containing densely packed enhancers that have combinatorial and additive activity and that are usually found to be associated with cancer . . .

     

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