Isc10, an inhibitor of the smk1 mapk, prevents activation loop autophosphorylation and substrate phosphorylation through separate mechanisms

HIGHLIGHTS

• who: Abhimannyu Rimal from the Abhimannyu Rimal, Thomas MSwayne, Zeal P. Kamdar, Madison A. Tewey, and Edward Winter* From the Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA Edited by Henrik Dohlman have published the article: Isc10, an inhibitor of the Smk1 MAPK, prevents activation loop autophosphorylation and substrate phosphorylation through separate mechanisms, in the Journal: (JOURNAL) of May/25,/2022
• what: The authors demonstrate Isc10 can inhibit the autophosphorylation of the mammalian intestinal cell kinase ICK1 (also known as CILK1), suggesting a conserved mechanism of action. In the experiments described . . .
  

   

  

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