HIGHLIGHTS
- who: Lais Silva from the p Cre/+ mice were bred to LSL-KrasG D/+ to produce p Cre/+ have published the research work: Pharmacological inhibition and reversal of pancreatic acinar ductal metaplasia, in the Journal: (JOURNAL) of 28/03/2022
- what: The intent of this study was to investigate how small_molecules affect ADM in_vitro. The authors focused on two pathways, histone deacetylation (HDAC) and Jak/Stat3. The authors show that a pStat3 inhibitor LLL12B and a HDAC inhibitor TSA impede ADM in p48Cre/+ and p48Cre/+;LSLKrasG12D/+ (KC) mouse organoids. For the experiments with 48-well . . .
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