Manipulation of tissue factor-mediated basal par-2 signalling on macrophages determines sensitivity for ifnγ responsiveness and significantly modifies the phenotype of murine dth

HIGHLIGHTS

• who: Hannah Wilkinson from the Stanford University, United States have published the research: Manipulation of tissue factor-mediated basal PAR-2 signalling on macrophages determines sensitivity for IFNu03b3 responsiveness and significantly modifies the phenotype of murine DTH, in the Journal: (JOURNAL)
• what: In the work the authors investigate the role of PAR-2 signalling on macrophages in_vitro and in the same murine DTH model described above. The authors also describe a novel therapeutic generated to exploit the highly novel findings the authors report; this has significant translational potential for clinically safe manipulation of these pathways . . .
  

   

  

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