HIGHLIGHTS
SUMMARY
Radiation therapy using charged particles has gained lots of attraction in the battle against cancer. Such geometrical and chemical variations at the interface of tissues or organs would alter the dose distribution of protons; this would in turn lead to changes in the Bragg peak location and make the proton range monitoring and verification tedious. The deposited dose in a target element (i.e., volume) could be measured by detecting annihilation radiation emitted as a result of generated positron emitting radionuclides (such as 15 O, 11 C and 13 N) produced through nuclear reactions . . .
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