The hippo pathway effector taz induces intrahepatic cholangiocarcinoma in mice and is ubiquitously activated in the human disease

HIGHLIGHTS

• who: Antonio Cigliano from the Institute of Pathology, University of Regensburg, Franzu2011Josefu2011Strauu00dfu2011Allee, Regensburg, Germany have published the Article: The Hippo pathway effector TAZ induces intrahepatic cholangiocarcinoma in mice and is ubiquitously activated in the human disease, in the Journal: (JOURNAL)
• what: The authors demonstrate that TAZ, in combination with AKT, induces the development of aggressive tumors with cholangiocellular features in the mouse liver. The authors focused specifically on AKT, a central player in cell survival and a protooncogene often activated in mouse and human iCCA . The authors comprehensively investigated the role of TAZ in cholangiocarcinogenesis . . .
  

   

  

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