Neurofilament light as a predictive biomarker of unresolved chemotherapy-induced peripheral neuropathy in subjects receiving paclitaxel and carboplatin

HIGHLIGHTS

• who: B. L. Burgess from the (UNIVERSITY) have published the research: Neurofilament light as a predictive biomarker of unresolved chemotherapy-induced peripheral neuropathy in subjects receiving paclitaxel and carboplatin, in the Journal: Scientific Reports Scientific Reports
• what: This analysis was limited to subjects that remained on treatment until end of cycle 9 (day 189), the final cycle in which an AE associated with CIPN was reported (Fig 1). This study provides the first evidence that serum NfL, a well-established biomarker of axonal injury, predicts onset of paclitaxel and carboplatin induced CIPN.
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