Aβ oligomer concentration in mouse and human brain and its drug-induced reduction ex vivo

HIGHLIGHTS

  • who: Bettina Kass from the 2428, Germany have published the article: Au03b2 oligomer concentration in mouse and human brain and its drug-induced reduction exu00a0vivo, in the Journal: (JOURNAL) of May/17,/2022
  • what: The authors demonstrate dose- and time-dependent oligomer elimination by the compound RD2 mouse and human AD brain homogenates as sources of native Such ex vivo target engagement analyses with mouse- and human-brain-derived have the potential to enhance the translational value from pre-clinical proof-of-concept studies to clinical trials. The authors demonstrate the usefulness of sFIDA to . . .

     

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