HIGHLIGHTS
- who: PGC- et al. from the DepartmentUniversity of Pennsylvania, USA have published the Article: HPV E6 regulates therapy responses in oropharyngeal cancer by repressing the PGC-1u03b1/ERRu03b1, in the Journal: (JOURNAL) of February/23,/2022
- what: This study evaluated whether variations in HPV oncoprotein levels among HPV+ OPSCCs contribute to diversity in their responses to cisplatin and radiation. This analysis provided models for subsequent experiments to pursue mechanistic determinants of these metabolic features and assess their impact on therapy response. The authors provide evidence that differing fl-E6 levels across HPV+ cancers variably repress . . .
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