Drug resistance in multiple myeloma: soldiers and weapons in the bone marrow niche

HIGHLIGHTS

  • who: Antonio Giovanni Solimando from the United States Department of Biomedical Sciences and Human Oncology, School of Medicine, u2018Aldo Moro` University have published the Article: Drug resistance in multiple myeloma: Soldiers and weapons in the bone marrow niche, in the Journal: (JOURNAL)
  • what: The finding that MCL-1, an inhibitor of apoptosis, and BCL-2 levels are modulated by the tumorassociated microenvironment has stimulated further investigation focused on MCL-1 inhibition.

SUMMARY

    Recent advances in the treatment of MM include the use of novel therapeutic strategies, such as immunomodulatory drugs (thalidomide . . .

     

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