HIGHLIGHTS
SUMMARY
Such advantages make NMR an ideal tool for a number of analytical applications such as targeted or untargeted metabolomics, stable-isotope-resolved studies of metabolism, pharmacokinetic studies, and bioprocess opti- mization (Zhang et_al, 2010; Wang et_al, 2013; Zhang et_al, 2008; Calvani et_al, 2010; Liu et_al, 2010; Strickland et_al, 2017; Emwas et_al, 2019; Kim et_al, 2013; Wishart, 2008). NMR suffers from poor sensitivity, which limits the detection of metabolites to the micromolar concentration range (in contrast, the limit of detection of mass spectroscopy can reach sub-nanomolar concentrations; Grotti et_al, 2009; Liem-Nguyen et_al, 2015 . . .
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