HIGHLIGHTS
- who: Richard A. Voit from the (UNIVERSITY) have published the article: A genetic disorder reveals a hematopoietic stem cell regulatory network co-opted in leukemia, in the Journal: (JOURNAL) of 22/02/2022
- what: The authors show that this transcriptional network is co-opted in high-risk leukemias, thereby enabling these cancers to acquire stem_cell properties. The authors have followed up on the human genetic observation that MECOM haploinsufficiency results in early-onset bone marrow failure and by modeling this disorder in primary HSPCs, the authors show that the functional loss of HSCs is accompanied . . .
If you want to have access to all the content you need to log in!
Thanks :)
If you don't have an account, you can create one here.