HIGHLIGHTS
- who: Nathalie Ollivier from the (UNIVERSITY) have published the paper: A biomimetic electrostatic assistance for guiding and promoting N-terminal protein chemical modification, in the Journal: (JOURNAL) of 26/04/2022
- what: The authors show that introducing negatively charged phosphoserines in a reactant is a powerful means for directing and accelerating the chemical modification of proteins equipped with oppositely charged arginines. The authors show that electrostatic assistance synergizes with amine catalysts to promote hydrazone formation. Although this experiment shows the importance of module overall charge on electrostatic assistance, it reveals that a phosphoserine residue cannot . . .
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