Epigenomic profiling of glucocorticoid responses identifies cis-regulatory disruptions impacting steroid resistance in childhood acute lymphoblastic leukemia

HIGHLIGHTS

• who: Brennan P. Bergeron from the (UNIVERSITY) have published the paper: Epigenomic profiling of glucocorticoid responses identifies cis-regulatory disruptions impacting steroid resistance in childhood acute lymphoblastic leukemia, in the Journal: (JOURNAL) of 26/08/2022
• future: Future directions should center on defining molecular mechanisms that link Wnt signaling to GC resistance as well as follow-up Leukemia 362374 - 2383

SUMMARY

Because the mechanism of action for GCs involves activation of the GR TF and the impact of transcriptional co-factors on GC resistance, disruption of GR binding_sites would also be . . .

 



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