Effects of apamin on mpp+-induced calcium overload and neurotoxicity by targeting camkii/erk/p65/stat3 signaling pathways in dopaminergic neuronal cells

HIGHLIGHTS

• who: Jihyun Park and colleagues from the Department of Pathology, College of Medicine, Catholic University of Daegu, Daegu, Republic of Korea have published the article: Effects of Apamin on MPP+-Induced Calcium Overload and Neurotoxicity by Targeting CaMKII/ERK/p65/STAT3 Signaling Pathways in Dopaminergic Neuronal Cells, in the Journal: (JOURNAL)
• what: The authors investigated whether APM affected 1-methyl-4-phenyl pyridinium (MPP+ )-mediated neurotoxicity in SH-SY5Y cells and rat embryo primary mesencephalic neurons. The authors evaluated the potential therapeutic effects of APM on the signal_transduction pathway involved in dopaminergic neurotoxicity.
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