Insulin-like growth factor reduces coronary atherosclerosis in pigs with familial hypercholesterolemia

HIGHLIGHTS

  • who: Sergiy Sukhanov and colleagues from the Tulane University have published the research work: Insulin-like growth factor reduces coronary atherosclerosis in pigs with familial hypercholesterolemia, in the Journal: (JOURNAL)
  • what: The authors report that IGF-1-induced FOS/FOSB downregulation correlated with CXCL14 gene_expression decrease in MF-high spots. The authors report here that IGF-1 administered over 6 months decreased coronary atherosclerosis and promoted features of stable atheroma in FH pigs, without evidence of a tumorigenic effect.
  • how: IVUS results and blood biochemistry data were analyzed using a 3-way repeated . . .

     

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