Nonhuman primate genetic models for the study of rare diseases

HIGHLIGHTS

• who: Eric J. Vallender from the Lynch syndrome (MLH1) Lynch Syndrome is the most common form of hereditary colorectal cancerThe disease is caused by inheritance of damaging mutations in one of four DNA mismatch repair genes that code for proteins essential to the DNA repair mechanisms in human cells. People who inherit a dysfunctional copy of one of these four genes (MLH1, MSH2, or PMS2) are at dramatically increased risk for colorectal cancer as well as tumors of the ovary, endometrium, stomach and other organs. More than one million people in the United States carry a Lynch . . .
  

   

  

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