Aberrantly activated apobec3b is associated with mutant p53-driven refractory/relapsed diffuse large b-cell lymphoma

HIGHLIGHTS

• who: Xuzhao Zhang from the Medical University, China have published the research work: Aberrantly Activated APOBEC3B Is Associated With Mutant p53-Driven Refractory/Relapsed Diffuse Large B-Cell Lymphoma, in the Journal: (JOURNAL)
• what: This study was approved by the ethics committee of the hospital and was conducted in accordance with the principles of the Declaration of Helsinki. The results of this study demonstrate that APOBEC3B induces p53 mutation and may confer drug resistance in DLBCL. In the present study, 3D-PCR-based sequencing identified TP53 exon 8 mutations in 35.9% of the cohort . . .
  

   

  

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