HIGHLIGHTS
SUMMARY
Trigeminal pain is especially characteristic of spinal pain in the orofacial area since it affects the trigeminal ganglion, a primary source of afferent neurons. Clinically, the term chronic orofacial pain has a disputed significance, and it refers to persistent, unrelenting pain in certain areas of the face and head. The understanding of chronic orofacial pain can be simplified by separating it into two main categories: musculoskeletal pain, and neuropathic pain. The potential therapeutic benefits of natural compounds against several pain-related conditions have also been demonstrated in_vivo and in_vitro studies reporting their anti-inflammatory . . .
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