A network approach for low dimensional signatures from high throughput data

HIGHLIGHTS

SUMMARY

    Four omics dataset were extracted from TCGA (The Cancer Genome Atlas) and made available at the Synapse homepage created by Yuan et_al20 (syn30​0013, doi:​10.​7303/​syn30​0013): kidney renal clear cell carcinoma (KIRC), glioblastoma multiforme (GBM), ovarian serous cystadenocarcinoma (OV) and lung squamous cell carcinoma (LUSC) (see "Materials and methods" and Supplementary Materials for further details). For each cancer type, the authors analyzed the mRNA, miRNA, and RPPA (protein) datasets, performing the classification of dichotomized survival o ­ utcomes20 via the same train/test subdivisions provided by Yuan et_al As already showed in . . .

     

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