Multi-omics analyses of men1 missense mutations identify disruption of menin-mll and menin-jund interactions as critical requirements for molecular pathogenicity

HIGHLIGHTS

• who: Koen M. A. Dreijerink from the Research Center (DKFZ), Heidelberg, Germany have published the research: Multi-omics analyses of MEN1 missense mutations identify disruption of menin-MLL and menin-JunD interactions as critical requirements for molecular pathogenicity, in the Journal: (JOURNAL)
• what: For global comparisons of menin-MLL or JunD interaction loss, the authors focused on WT menin- JunD peaks in the absence of MLL1/H3K4me3 peaks (cluster 4) and WT menin-MLL1/H3K4me3 peaks in the absence of JunD (cluster 5).
• how: By using ectopic expression the authors carried out quantitative . . .
  

   

  

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