HIGHLIGHTS
SUMMARY
For all known human proteins, and soon was extended to thousands of other genomes, became the input for structural genomics. The logic behind structural genomics seems straightforward today, but the task of determining "all basic protein shapes" was, in the 1990s, monumental. It was also at odds with the traditional practice of protein structure determination, which emphasized the more specific, biochemical application of structure. In contrast, structural genomics focused on providing "structural coverage" of protein families with the tacit understanding that protein modeling could tackle homologous members of such families (Rost 1998). Such a . . .
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