The role of membrane affinity and binding modes in alpha-synuclein regulation of vesicle release and trafficking

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  • who: Tapojyoti Das et al. from the Department of Biochemistry, Weill Cornell Medical College, New York, NY, USA Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, USA have published the paper: The Role of Membrane Affinity and Binding Modes in Alpha-Synuclein Regulation of Vesicle Release and Trafficking, in the Journal: Biomolecules 2022, 1816 of 21/09/2022
  • what: Using structural and functional characterization of conformationally selective mutants via a combination of spectroscopic and cellular assays the authors show here that binding affinity for isolated vesicles similar in size to synaptic vesicles is . . .

     

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