Disease-associated h58y mutation affects the nuclear dynamics of human dna topoisomerase iiβ

HIGHLIGHTS

• who: Keiko Morotomi-Yano from the InstitutKumamoto University have published the paper: Disease-associated H58Y mutation affects the nuclear dynamics of human DNA topoisomerase IIu03b2, in the Journal: Scientific Reports Scientific Reports
• what: The authors characterized the nuclear dynamics of TOP2B H58Y in comparison with TOP2B WT and other TOP2B mutants.
• how: For FRAP curve fitting by non-linear regression the authors used the Stowers ImageJ plugins (https//u200breseau200brch.u200bstoweu200brs.u200borg/u200bimageu200bjplugu200bins/u200bImageJ_u200btutoru200bial2.u200bhtml) in the u00adFiji58 (ImageJ version 1.53t) according to the procedures described u00adpreviously59.

SUMMARY

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