HIGHLIGHTS
- who: Nils Korte and collaborators from the DepartmentUniversity College for Neurology and Neurosurgery, London, United Kingdom have published the Article: The Ca2+-gated channel TMEM16A amplifies capillary pericyte contraction and reduces cerebral blood flow after ischemia, in the Journal: (JOURNAL)
- what: The authors show that a small rise in cytoplasmic Ca2+ concentration ([Ca2+]i) in pericytes activated chloride efflux through the Ca2+-gated anion channel TMEM16A thus depolarizing the cell and opening voltage-gated calcium channels. Using experiments in brain slices and in_vivo, the authors demonstrate here that TMEM16A is a crucial amplifier of cortical . . .
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