5mc modification patterns provide novel direction for early acute myocardial infarction detection and personalized therapy

HIGHLIGHTS

SUMMARY

    Researchers discovered that by altering DNA methylation, 5mC regulators (methyl transferase: writers; signal transducers: readers; and demethylase: erasers) are essential for a variety of cellular biological activities, including the silencing of retroelements, the stabilization of centrioles, and the regulation of gene_expression. Studies examined 5mC regulators and molecular typing based on 5mC regulator gene_expression are still limited. The expression value was pre-processed by the "normalize between arrays" function in the "limma" package, and differential gene_expression analysis was conducted. By using "rms" package, the authors developed a 5mC regulator-related AMI-CAD classifier based on . . .

     

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