Reduction of protein disulfide isomerase results in open conformations and stimulates dynamic exchange between structural ensembles

HIGHLIGHTS

  • who: Mathivanan Chinnaraj from the Mathivanan Chinnaraj1, Robert Flaumenhaft2, *, and Nicola Pozzi1, * From the Edward ADoisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St Louis, Missouri, USA have published the article: Reduction of protein disulfide isomerase results in open conformations and stimulates dynamic exchange between structural ensembles, in the Journal: (JOURNAL) of May/23,/2022
  • what: The authors show that the redox environment dictates the time spent in each ensemble and the rate at which they exchange. The authors show that irreversible inhibitors targeting the active_sites of reduced PDI did . . .

     

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